temozolomide

Mechanism of Action. keluaran macau sdy sgp hk Temozolomide is a prodrug which is rapidly and nonenzymatically converted to the active alkylating metabolite MTIC [ (methyl-triazene-1-yl)-imidazole-4-carboxamide]; this conversion is spontaneous, nonenzymatic, and occurs under physiologic conditions in all tissues to which it distributes (Marchesi 2007; Villano 2009)